The RUNX1/RUNX1T1 (former named AML1/ETO) DNA-FISH Probe is designed to detect the translocation involving the AML1 (RUNX1) gene on chromosome 21q22 and the RUNX1T1/ MTG8 gene on chromosome 8q22 by fluorescence in situ hybridization (FISH). This translocation generates an fusion protein and is detected in 12% of de novo AML cases and in up to 46% of cases in the AML subtype M2.[1,2] The detection of the t(8;21) is clinically relevant because it is generally associated with a favorable prognosis and particularly with high-dose cytorabine-based consolidation chemotherapy.
